Titlebook: CPP, Cell-Penetrating Peptides; Ülo Langel Book 2023Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive licens

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https://doi.org/10.1007/978-981-10-5753-3Here, the brief summary of therapeutic developments and current situation with applications of CPPs is presented, hopefully leading to multiple CPP based drugs in near future.

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Folk Conceptualizations Across LanguagesIn this chapter, the delivery of biomolecules such as oligonucleotides, proteins, peptides and others by connection of the power of modern nanoparticles with the flexibility and efficacy of CPPs is summarized. This will increase the potential of therapeutic agents, requiring protection from degradation and release in a controlled manner.

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Classes and Applications of Cell-Penetrating Peptides,Possibilities for classification of CPPs based on their type of origin, biochemical properties, and physico-chemical properties are presented together with examples. Eight different and arbitrary levels for classification are presented, due to their partly overlapping properties.

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Methods for CPP Selection, Prediction and in Silico Analysis,This Chapter summarizes the methods for (initial) CPP selection, identification or design of CPPs by prediction. These studies deal mainly with multiple peptide sequences, shorter or longer, linear or cyclic, consisting of ribosomally coded or non-coded amino acids.

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Labeling of CPPs,This Chapter summarizes the multiple methods for labeling used in CPP research. Most of the methods of chemistry, biophysics, biochemistry, cell signaling, molecular biology, imaging etc., has been used to understand the action of CPPs.

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Targeting Specific Barriers,In this Chapter, the targeting strategies of CPP and CPP/cargo complexes to specific cells or intracellular organelles are summarized, and their potential for pharmacological or clinical use is briefly discussed.

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