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Titlebook: COX-2 Inhibitors; Michel Pairet,Joanne Ryn Book 2004 Springer Basel AG 2004 Alzheimer.NSDAIDSs.alzheimer‘s disease.analgesic effects.cance

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Social Influence in Social Contexts,asses of inhibitors. The particular advantage of molecular modelling approaches is that they allow us to visualize and rationalize the recognition process of substrates and inhibitors by COX isoenzymes [2].
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How the Mind Took Over the World,d protective effects) while COX-2, which is induced by inflammatory stimuli, is considered to be important in inflammation, pain and fever [1–5]. Comprehensive reviews on the regulation and roles of these two isoenzymes in inflammation are found in [1–9] and Figure 1 summarizes their essential features.
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Effects on the lungs: role of COX-2 inhibitors,rently suboptimal therapeutic options. In this chapter, we will first outline data regarding COX-2 expression in the lung. We will then focus on various lung disease models in which COX-2 expression is increased and is thought to have a pathogenic role, and then review investigations in which COX-2 inhibition has altered these models (Tab. 1).
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Structural diversity of selective COX-2 inhibitors,
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COX-2 and the cardiovascular system,hysiological” and “pathological” COX pathways is somewhat artificial [6–9]. Perhaps even more intriguing was the finding that COX-2 is hydraulically expressed in vascular endothelium . and this isoform, and not constitutive COX-1, contributes to the formation of prostacyclin (PGI.) [10]. It is now k
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