Titlebook: COX-2 Inhibitors; Michel Pairet,Joanne Ryn Book 2004 Springer Basel AG 2004 Alzheimer.NSDAIDSs.alzheimer‘s disease.analgesic effects.cance

退潮

警告

Introduction: Philosophy and the Novel,ociated with inflammatory conditions [1]. However, it soon became apparent that aspirin could cause gastrotoxicity, a fact demonstrated unequivocally in 1938 by the endoscopic studies of Douthwaite who observed erosions and ulcers in the gastric mucosa of patients on long-term aspirin therapy [2].

教唆

heterodox

Acupressure

capillaries

圆桶

奴才

Role of COX-2 in ulcers and ulcer healing,history of previous ulcers, concomitant anticoagulation or corticosteroid use and high dose NSAIDs [3]. Use of low-dose aspirin approximately doubles the risk of bleeding in patients taking NSAIDs [3–4].

Inveterate

摆动

The molecular and biological basis for COX-2 selectivity,asses of inhibitors. The particular advantage of molecular modelling approaches is that they allow us to visualize and rationalize the recognition process of substrates and inhibitors by COX isoenzymes [2].