Titlebook: CNS Complications of Malignant Disease; J. M. A. Whitehouse (Director of the CRC Medical O Book 1979 The contributors 1979 central nervous

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Overview: 978-1-349-04285-2

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Histopathogenesis of Meningeal Leukaemia and Complications of Therapyumber of new antileukaemic drugs which were capable of prolonging initial remissions. Although these early achievements made it clear that bone marrow leukaemia could be controlled by chemotherapy, meningeal infiltration proved much more resistant; the inability to prevent relapses in the central ne

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Prevention and Treatment of Central Nervous System Leukaemia in Childhoodrvous system (CNS) leukaemia emerged as a significant problem (Sansone, 1954; Sullivan, 1957; Gilbert and Rice, 1957; Zuelzer and Flatz, 1960; Evans, 1964). The importance of extramedullary involvement increased directly with success in achieving and prolonging haematological remissions. Although an

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Prevention of Central Nervous System Leukaemia in Acute Lymphoblastic Leukaemia with Prophylactic Chg intensive treatment regimens in children and adults with acute lymphoblastic leukaemia (ALL). In addition to attempting to improve the incidence and duration of remissions, one of the main objectives of these trials was to see if it would be possible to prevent central nervous system (CNS) leukaem

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Problems in Management of Childhood CNS Leukaemiaadditional CNS therapy, meningeal leukaemia recurs within a median time of around three months (Selawry and Odom, 1968; Sullivan .., 1975a). Recurrence can be delayed by maintenance monthly, or 6–8 weekly, intrathecal (IT) injections of methotrexate (MTX) (table 5.1), but permanent eradication of me

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A Study of the Prognostic Factors of Central Nervous System Leukaemia in Acute Lymphoid Leukaemia Paaemia (ALL). As shown by Pinkel (1973), Simone (1974) and by us (Pouillart .., 1972), the treatment of established CNSL is less successful than prophylaxis, and the occurrence of meningeal relapse is usually associated with a poor prognosis of the disease. It is now generally accepted that treatment