Titlebook: Atypical Breast Proliferative Lesions and Benign Breast Disease; Farin Amersi,Kristine Calhoun Book 2018 Springer International Publishing

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Breast Cancer Risk Prediction in Women with Atypical Breast Lesions,35%, or approximately 1% per year, although more recent studies suggest the risk is higher. Women with atypical ductal and lobular hyperplasia are four times more likely to develop breast cancer than the general population. Atypical hyperplasia confers a cumulative incidence of breast cancer of nearly 30% at 25 years.

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,Diagnostic Management of the Atypical Hyperplasias: Core Biopsy Alone Versus Excisional Biopsy, to have a substantial risk of upgrade. In contrast, some patients with ALH on CNB with concordant pathologic, radiologic, and clinical information have a relatively low risk of upstaging on excision. Therefore, patients with ADH on CNB must be excised while a discussion of the risks and benefits are recommended for patients diagnosed with ALH.

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Diagnostic Management of LCIS: Core Biopsy Alone Versus Core Biopsy plus Excision for Classic Versues, concordant radiological-pathological findings, and clinical presentations. Emerging data support that patients with CLCIS can be managed with chemoprevention and surveillance. On the other hand, PLCIS should be managed similar to DCIS, with surgical excision with or without radiation.

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,The Role of Chemoprevention in the Prevention of Breast Cancer,nd have favorable cost-benefit profiles for the prophylactic use of breast cancer prevention medications. Despite the consistent data demonstrating that prevention medications reduce breast cancer risk, mean uptake and adherence to these medications in eligible patients remain low.

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