Titlebook: Atypical Antipsychotics; Bart A. Ellenbroek,Alexander R. Cools Book 2000 Springer Basel AG 2000 dopamine.research.schizophrenia.serotonin.

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Milestones in Drug Therapyhttp://image.papertrans.cn/b/image/164936.jpg

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https://doi.org/10.1007/978-3-642-80732-9 execution of voluntary motor action. Although the course of the illness varies greatly between individuals, the characteristic time-course includes episodes of florid illness superimposed upon a level of chronic disability. The degree of chronic disability ranges from a relatively mild reduction in

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Jochen Ludewig,Martin Glinz,Hans Matheischotic drugs that had been available for some three decades or more, most commonly perphenazine and haloperidol, with an additional 2% receiving loxapine and 13% receiving clozapine [.]. Since the identification in the 1950s of chlorpromazine as the archetype antipsychotic, a profound advance that h

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https://doi.org/10.1007/978-3-642-70639-4n identified. The main reason for this, apart from the difficulties in diagnosis (see Liddle, this volume), is the limited accessibility of the human brain. Until about 20 years ago, the investigation of the brains of patients was limited to.analysis. This technique (with a high spatial resolution)

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Jochen Ludewig,Martin Glinz,Hans Matheishe most considered are the dopaminergic [.], the serotonergic (5-hydroxytryptamine, 5-HT) [..] and the glutamatergic systems [.]. The hypotheses essentially emerged from clinical observations with drugs, whose properties became well-documented in pharmacological and biochemical studies. Today’s know

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https://doi.org/10.1007/978-3-642-70639-4fficacy, the incidence of side-effects (especially the extrapyramidal side-effects) differs between individual drugs. This has already been known for a long time, but the earlier studies were largely overlooked. Among the earlier papers were a number of clinical studies comparing several phenothiazi

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https://doi.org/10.1007/978-94-6091-982-4of these compounds. In the early times of the dopamine (DA) hypothesis of schizophrenia animal models were designed to detect compounds which blocked the behavioural effects of high doses of dopaminergic drugs (e.g. amphetamine-, apomorphine-and methylphenidate-induced stereotyped behaviour). When.r

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