Titlebook: Asbestos and Mesothelioma; Joseph R. Testa Book 2017 Springer International Publishing AG 2017 Asbestos.Cancer Prevention.Cell Signaling.E

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Malignant Pleural Mesothelioma: History, Controversy, and Future of a Man-Made Epidemic,g non-invasive biomarkers such as mesothelin, the 13-protein signature in serum, fibulin-3, circulating microRNAs and the recently discovered BAP1 cancer syndrome are highlighted. The asbestos history is a lesson not be repeated, but here we also review recent in vivo and in vitro studies showing th

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3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival,optotic family expression, and autophagy. In general, cells in a 3D setting show many differences compared to the same cells in a 2D monolayer. Many of these differences appear to contribute to cell survival. In many cases, these features can be shown to be more similar to those in the actual tumor.

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Biomarkers of Response to Asbestos Exposure,onchoalveolar lavage fluid. This makes direct exposure assessments very difficult. In contrast, biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, have proved to be more useful. MM is the major biological response to asbestos that can be readily mon

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Immunotherapeutic Approaches to Mesothelioma,Of these, the monoclonal antibody amatuximab and an antibody-drug conjugate anetumab ravtansine are undergoing registration trials. Ongoing research is focused on better understanding the antitumor responses to immune-based approaches and to prospectively identify patients who are more likely to res

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