Titlebook: Arenaviruses II; The Molecular Pathog Michael B. A. Oldstone Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive lic

带伤害

Moleküle: Ohne sie gäbe es kein Lebener enables T cells to specifically recognize peptides presented by major histocompatibility complex (MHC) molecules and generate an immune response to those peptides. CD4. helper T cells are restricted to MHC class II molecules, and produce cytokines to augment T and B cell responses. CD8. T cells a

eulogize

Expeditions as Experiments: An Introduction,n systems. Second, as discussed in this chapter, the anti-viral immune response can be harmful, in contrast and addition to its beneficial effect of eliminating or decreasing the viral load. For example, cytokines and chemokines secreted by cells and other components of the immune system can have de

Morbid

Expeditions as Experiments: An Introduction,ly benefited from the use of lymphocytic choriomeningitis virus (LCMV) infection of its natural host, the mouse. One of the strengths of the LCMV system is its flexibility: infection can result in dramatically distinct outcomes in mice depending on variables such as host age, immunological competenc

凶残

W. M. F. Mansvelt,P. Creutzbergytic choriomeningitis virus (LCMV) and of 44%–63% for homologous proteins of different arenaviruses: LCMV, Pichinde, Junin, Machupo and Lassa (. and . 1987; . and . 1988). Yet considerable variation in biological properties among LCMV strains soon became apparent (reviewed in . and . 1983; . and . 1

ALE

W. M. F. Mansvelt,P. Creutzberg; Machupo virus) and Venezuelan hemorrhagic fever (VHF; Guanarito virus) are caused by arenaviruses. These diseases can be devastating, and often lethal. LCMV, the prototype of the Arenaviridae, can cause aseptic meningitis, and is a known teratogen. Despite the pathogenicity of the arenaviruses, to

追逐

https://doi.org/10.1007/978-3-663-12879-3logic agent of this disease, Junin virus (JUN), was isolated in 1958 (. et al. 1958; . et al. 1959). JUN belongs to the Arenaviridae family, which includes other rodent-borne pathogens which are important causes of hemorrhagic fever in Africa, (Lassa) and South America (Machupo, Guanarito, and Sabia

秘密会议

dapper

Evolution: Vom Molekül zum Organismus remarkable flexibility of the LCMV system has also allowed for the exploration of different experimental strategies generating a complex of answers that appears appropriate to the multifaceted and intricate nature of diseases whose prevention or treatment may be improved by the adoptive transfer of immunologically active cells.

spinal-stenosis

interlude

Expeditions as Experiments: An Introduction,re combined, the consequences of infection range from rapid onset, immune-mediated mortality to lifelong persistent infection in the absence of overt illness. While all of these outcomes can be induced in laboratory mice, mother-to-offspring transmission resulting in persistent LCMV infection predominates in the wild.