Titlebook: Aptamers for Medical Applications; From Diagnosis to Th Yiyang Dong Book 2021 Springer Nature Singapore Pte Ltd. 2021 Aptamer.SELEX.Drug De

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Aptamer-Based Point of Care Testing Schemes,eing considered for use in point-of-care testing (POCT). Relevant technologies include lateral flow test strips, interferometry, DNA origami nanoboxes, capacitive aptasensors, microfluidics, nanoparticle-based aptasensors, and multiplex technologies suitable for rapid and facile POCT schemes. Advant

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Aptamer-Based Drug Delivery Systems,he side effects. Aptamers are single-stranded RNA or DNA with high binding affinity and specificity against their corresponding targets, such as metal ions, peptides, proteins, and living cells. Compared with classic antibodies, aptamers have many superiorities, such as small size, little immunogeni

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Aptamers for Targeted Therapy,athy, blood coagulation, inflammation, and cancer, and there are increasing numbers of evidences to prove the clinical application potential of aptamers. To date, more than a dozen aptamers have entered clinical trials as therapeutic agents for targeted therapy. This chapter introduces their pharmac

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Aptamers for Personalized Therapeutics,e modern diagnosis, bioimaging, drug delivery, and more specifically in personalized therapeutics. Aptamers have the potential of serving as therapeutic molecules alone but they are more effective in combination with drugs and nanomaterials for the sake of targeting or as delivery agents against bro

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Aptamers for the Diagnosis of Infectious Diseases,logical information have been successfully applied in infection diagnosis. However, these methods are either relatively complicated or time-consuming. Aptamer, a specific DNA/RNA binder, can serve as field-deployable sensors (termed aptasensors), and is thus highly promising to construct point-of-us

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Aptamers for the Diagnosis of Malign Tumors,to improve the strategy of early diagnosis for malign tumors. Aptamers are single-stranded oligonucleotide ligands with excellent chemical properties such as high affinity, easy synthesis, controllable chemical modifications, low immunogenicity, high stability, and fast tissue penetration. Therefore

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Aptamers for Thrombotic Diseases, (AMI), acute coronary syndromes (ACS), and thrombotic diseases. Nowadays, thrombotic diseases are the leading causes of morbidity and mortality which incur substantial healthcare expenditures worldwide. There are some shortcomings for current antithrombotics including bleeding potential, unpredicta