Titlebook: Antiviral Drug Discovery and Development; Xinyong Liu,Peng Zhan,Vasanthanathan Poongavanam Book 2021 The Editor(s) (if applicable) and The

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Covalent Antiviral Agents,tically increased. Hence, there is a pressing need to design potent broad-spectrum antiviral agents to treat a variety of viral infections and overcome viral resistance. Covalent inhibitors have the potential to achieve both goals owing to their biochemical efficiency, prolonged duration of action,

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Safe-in-Man Broad Spectrum Antiviral Agents,als does not adequately allow for proper preparedness in the face of unknown future epidemics. In addition, drug developers lack the financial incentives to work on antiviral drug discovery, with most pharmaceutical companies choosing to focus on more profitable disease areas. Safe-in-man broad spec

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Exploiting Ubiquitin Ligases for Induced Target Degradation as an Antiviral Strategy,tein that tags substrates with a single molecule or with a polyubiquitin chain. Monoubiquitination affects trafficking and signaling patterns of modified proteins. In contrast, polyubiquitination, particularly K48-linked polyubiquitination, targets the protein for degradation by the Ubiquitin-Protea

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https://doi.org/10.1007/978-981-16-0267-2Antiviral drugs; enzyme inhibitors; drug design; antiviral therapy; viral infections

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Antiviral Drug Discovery and Development978-981-16-0267-2Series ISSN 0065-2598 Series E-ISSN 2214-8019

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https://doi.org/10.1007/978-3-319-02189-8 efforts during the last 40 years have led to the approval of over 30 antiretroviral drugs and the introduction of combination therapies that have turned HIV infection into a chronic but manageable disease. In this chapter, we provide an update on current available drugs and treatments, as well as f