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Titlebook: Antirheumatic Therapy: Actions and Outcomes; Richard O. Day,Daniel E. Fürst,Barry Bresnihan Book 2005 Birkhäuser Basel 2005 Arthritis.auto

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Azathioprine,d thioguanylic acid. These metabolites inhibit intracellular function by interfering with adenine and guanine ribonucleotide production through suppression of inosinic acid synthesis [.. These effects result in downregulation of actively proliferating cells with a particular effect on bone marrow.
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Methotrexate, cytotoxic effect on proliferating lymphocytes. Subsequently its efficacy in RA was proven in a series of papers in the mid 1980s and it is now the mainstay of RA therapy, both alone and in combination, as recommended in the guidelines of the American College of Rheumatology 2002 [.].
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