Titlebook: Antimutagenesis and Anticarcinogenesis Mechanisms; Delbert M. Shankel,Philip E. Hartman,Gregory Kuny Book 1986 Springer Science+Business M

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https://doi.org/10.1007/978-1-4684-2058-6o two parts by Kada (5): desmutagenesis and antimutagenesis per se. Desmutagenesis refers to inactivation of mutagens and carcinogens by whatever means, whether by antioxidants, by cytochrome P-450-associated activity, or by the active destruction or absorption of the toxic substances before they ca

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Electrochemistry for the Environmentorms as well as in the binding of these activated species to DNA. In this chapter, a general introduction to free radical chemistry is presented, with some discussion of radical lifetimes and reactivities. Potential biological targets of radical attack include lipids, proteins, and nucleic acids, an

起来了

Theme and Objectives of the Conferenceydrocarbons, carcinogens, and mutagens, are catalyzed by the cytochrome P-450-dependent drug metabolism system (5). This system is found in the endoplasmic reticulum of various mammalian tissues and organs, e.g., lung, small intestines, etc. (20, 24), but the greatest concentration and activity are

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多节

Electrochemistry in Ionic Liquidsnitrosating agents such as nitrite or nitrosating gases encounter nitrosatable amines. To date, more than 300 NOCs have been tested in animals, and about 90% of them produced tumors in 40 animal species, including primates. Humans are exposed to NOCs from exogenous and endogenous sources through nit

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https://doi.org/10.1007/978-3-319-13485-7ed to mutation; (b) promotion, a process during which cells undergo phenotypic changes, some of which are referred to as preneoplastic, and a proportion of which attain autonomy when they can be regarded as neoplastic; and (c) progression, a period of continuing phenotypic diversification during whi

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https://doi.org/10.1007/978-3-319-15132-8r repair the deleterious influence of noxious chemicals in the environment on DNA. Animals tend to defend themselves through the use of enzymes which intercept aggressive chemicals and convert them to less dangerous substances. Animal cells also contain a variety of preformed smaller molecular weigh

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Electrochemistry in Research and Development (8, 49). More recently, a number of mutagens have been detected in our environment and their genotoxicities recognized (45). Therefore, it is necessary to have knowledge about antimutagens and their modes of action in order to assess the genotoxic nature of our environment. Crow (9) considers that