Titlebook: Antibody Engineering Protocols; Sudhir Paul Book 1995 Humana Press 1995

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Preparation and Assay of Acetylcholinesterase Antibody,pproach consists of exploiting the internal image properties of anti-idiotypic antibodies to produce catalytic antibodies. In the first step, an antibody is raised that recognizes the active site of an enzyme. The binding site of this first antibody (Ab1) has structural features complementary to tho

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实施生效

https://doi.org/10.1007/978-3-658-10327-9s cannot be diagnosed by the mere finding of increased titers of autoantibodies in serum. The question arises whether the structure, specificity, affinity, idiotypy, and genetics of autoantibodies in healthy subjects differ from those of pathological autoimmunity (.,.). Determining the fine specific

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Formale Soziologie (Beziehungslehre),pproach consists of exploiting the internal image properties of anti-idiotypic antibodies to produce catalytic antibodies. In the first step, an antibody is raised that recognizes the active site of an enzyme. The binding site of this first antibody (Ab1) has structural features complementary to tho

Institution

https://doi.org/10.1007/978-3-476-02844-0lows the construction of a suitable mimic of the transition-state or other high-energy structures. Individual approaches explore the scope of the antibody’s enzymatic qualities and the validity of the design strategy for generating the catalyst. The success of these endeavors typically requires seve

Calculus

,Praktische Hinweise und Lektürevorschläge,of the catalytic activity, we have cloned and expressed the light (L)-chain subunit and single-chain F. (scF.) fragment of one such antibody. The recombinant L chain and the scF. display interactions with VIP typical of an antibody-combining site. Both molecules are efficient catalysts (.). The dist

Ebct207

Molecular Modeling of Antibody-Combining Sites,-ray crystallographic structures and good solution structures of free and antigen-bound antibodies. The number of reported antibody structures grows each year. Yet the number of structures deposited with the Brookhaven Protein Database (PDB) (.) remains relatively small, with 43 deposited entries at

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