Titlebook: Antibacterials; Volume I Jed F. Fisher,Shahriar Mobashery,Marvin J. Miller Book 2018 Springer International Publishing AG, part of Springer

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Synergistic Antibiotic Combinations,n the two are combined. Because of increasing antibiotic resistance, and few new drugs to treat multidrug-resistant bacteria, combination therapy is often used in the clinical setting. Frequently, these combinations have demonstrated synergistic activity both in vitro and in animal models before bei

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The Clinical Development of Antibacterial Drugs: A Guide for the Discovery Scientist,opment process. To meet this challenge, an innovator must have a basic understanding of those steps in this process that demand far more than knowledge of basic bench science. Perhaps the most difficult of these steps involves an understanding of regulatory and clinical development issues that only

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Four Ways to Skin a Cat: Inhibition of Bacterial Topoisomerases Leading to the Clinic,st through Phase 2 clinical trials. Compounds from each of the four classes are not cross-resistant to one another as determined by analyses with laboratory and clinical resistant bacterial strains. Hence, they are defined herein as sharing a mode of action, in that they inhibit the same targets, bu

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Book 2018hroughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known

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Philosophisch-psychologische Vorbemerkungen,lly with no clinical data to support their use. Because combination therapy will continue to be used in the absence of supportive clinical data, it will be important in the future to investigate mechanistic principles that may lead to predictive models for successful patient outcomes.

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