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Titlebook: Anti-Inflammatory Drugs in Asthma; Anthony P. Sampson,Martin K. Church Book 1999 Springer Basel AG 1999 Atmen.allergy.asthma.cytokine.rese

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期刊全称Anti-Inflammatory Drugs in Asthma
影响因子2023Anthony P. Sampson,Martin K. Church
视频video
学科分类Progress in Inflammation Research
图书封面Titlebook: Anti-Inflammatory Drugs in Asthma;  Anthony P. Sampson,Martin K. Church Book 1999 Springer Basel AG 1999 Atmen.allergy.asthma.cytokine.rese
影响因子For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introduced by a broad survey of the targets for anti-inflammatory drugs, this book proceeds to bring together the most recent research into the mechanisms and clinical benefits of presently available anti-inflammatory treatments including corticosteroids, cromones, and theophylline. For the first time, these drugs are discussed alongside the newly introduced leukotriene modifier drugs, and in the context of frontline research into anti-inflammatory drugs of the future. Leading authorities in their fields evaluate the prospects of novel anti-IgE agents and cytokine antagonists, and examine recent developments in immunosuppressant compounds, protease inhibitors, and selective phosphodiesterase inhibitors. This book is an up-to-date and authoritative survey which will be invaluable to university and pharmaceutical company researchers working on anti-asthma and anti-allergy drugs and to respiratory physicians keeping abreast of developments in the
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,β2-Agonists, a coupling G-protein and adenylate cyclase, the effector enzyme [3] (Fig. 1). Cyclic AMP is able to modulate a number of processes which are important in governing the contractile state of the cell [4].
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Anti-IgE Agents,to have a crucial role in the generation and persistence of symptoms in allergic diseases. The development of drugs that interfere with IgE production and function may therefore represent a more specific approach to treat these pathological conditions [1, 2].
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Marta Mierendorff,Heinrich Tostorphonuclear cells, mast cells, and macrophages are present in an activated state and release proinflammatory mediators, cytokines and growth factors. From inflammation, a process of healing and repair may follow and this has been postulated to lead to remodeling of the airways.
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https://doi.org/10.1007/978-3-663-02006-6e numerous in the bronchial mucosa [2], submucosa and alveolar walls [3], and are even found free in the lumen [4]. The activation of mast cells by allergen or by other stimuli is associated with the rapid release of a range of potent mediators of inflammation and bronchoconstriction.
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