Titlebook: Angiogenesis in Health, Disease and Malignancy; Ali Salajegheh Book 2016 Springer International Publishing Switzerland 2016 Gene function.

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Adenosine Triphosphate-Binding Cassette (ABC) Lipid Transporters,s accountable for intracellular cholesterol homeostasis with a protective role in the cardiovascular system. There were limited evidence in the relationship between ABCA1 and ABCG1 and cancer. The majority of research of ABC transport in cancer was mainly derived from its role in cholesterol efflux

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Angiogenin,as a neuroprotective role. Cancer viability and spread is also supported by the expression of ANG in many malignancies. Angiogenin drives tumour angiogenesis, promote cancer growth and metastasis by induction of ribosomal RNA transcription that enables angiogenesis initiation by VEGF and other vascu

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Angiopoietins,, in parenchymal cells of the extravascular tissue and some malignant cells. In malignancies, Ang-1 has been shown as a promoter of vessel stabilization in the later stages of developmental angiogenesis and tumours’ stabilisation and perfusion. Ang-2 is identified as one of the crucial factors in tu

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Cyclin D1 and E1,cogene. CCND1 plays several roles in the progression of cancer via its potential contribution to uncontrolled proliferation through its involvement in cell cycle regulation and the promotion of the process of Angiogenesis via its involvement in the regulation of the Vascular Endothelial Growth Facto

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COX 10,ochondrial electron transport chain in aerobic respiration, and hence it can be concluded that hypoxia-regulated miR-210 triggers the metabolic switch from aerobic to anaerobic respiration in cancer cells via downregulation of COX10. This, in turn, promotes the survival of tumour cells under hypoxic

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Erythropoietin-Producing Hepatocellular Receptors A: Ephrin A1, Ephrin A2 and Ephrin A3,n-A1’s diverse involvement in many organ systems around the body, it is studied as a potential therapeutic target to find the treatment for many abnormal conditions. The role of EphA2 in angiogenesis of tumours has a direct link to aggressive tumour vasculature and invasion. Lastly, the genetic alte

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Ets-1, Ets-1 factors and the overexpression of Ets-1 has been linked to the increased expression of these genes as well. In addition to this, Ets-1 is involved in regulating the invasiveness, metastatic potential and progression of tumours by regulating genes which influence cancer cell behaviour. Potenti