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Titlebook: Angiogenesis in Brain Tumors; Matthias Kirsch,Peter McL. Black Book 2004 Springer Science+Business Media New York 2004 angiogenesis.brain

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Histologic Measures of Angiogenesis in Human Primary Brain Tumorsrticular, tumor vascularity has known importance in astrocytomas, in which endothelial proliferation is a criterion for anaplasia in many grading schemes. This chapter summarizes the known associations of quantitated microvessel parameters obtained from histologic sections of human brain tumors with
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Methods to Study Angiogenesis ,ined easily from umbilical cord veins by incubation and subseqent flushing of the veins with enzymatic solutions (4). Cultures of human umbilical vein ECs (HUVECs) can be greatly expanded and usually retain markers of endothelial differentiation over more than ten passages until they eventually beco
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Angiogenesis-related Growth Factors in Brain Tumorsoblast growth factor, platelet-derived growth factor and transforming growth factor P. We review the expression pattern of these factors in gliomas, their functional contribution to tumor angiogenesis — also in relation to vascular endothelial growth factor, and the effects resulting from their inhi
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Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiologydeed, the ability to initiate homeostatic responses and adapt to hypoxia, e.g. by induction of angiogenesis, represents an important and crucial aspect in solid tumor growth. A significant advance in our understanding of the hypoxia response stems from the discovery of the hypoxia inducible factors
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