Titlebook: Aluminum and renal failure; Marc E. Broe,Jack W. Coburn Book 1990 Kluwer Academic Publishers 1990 anemia.diseases.infection.infections.met

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,Entwicklung und Durchführung der Empirie, and hematologic systems [1–4]. Early clinical reports suggested that aluminum deposition in brain was related to the development of a progressive and lethal encephalopathy in patients receiving maintenance hemodialysis. Many patients with the syndrome of dialysis encephalopathy, or dialysis dementi

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https://doi.org/10.1007/978-3-540-88613-6es do not accumulate large amounts of the metal within the body fluids and tissues. The slight increase in the aging brain [2, 3] is probably biologically irrelevant. These facts explain why aluminum is toxic only to animals artificially exposed to abnormal amounts of the metal. In such circumstance

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https://doi.org/10.1007/978-3-540-88613-6cal reactions, the small ionic radius and high charge (r=.51A; charge=3+) results in prolonged dissociation times compared to other biological cations and probably renders aluminum unsuitable or toxic to many biological systems. Nevertheless, many biological organisms have probably evolved in the pr

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https://doi.org/10.1007/978-3-540-88613-6r to form the species [Al(H.O).]., frequently written as Al.. At physiological pH (7.4) in aqueous solution and in the absence of potential ligands other than water, the coordinated water molecules lose protons leading to the hydrolysed species [Al(OH).]., an aluminium ion tetrahedrally surrounded w

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https://doi.org/10.1007/978-3-540-88613-6nd other elements within sections of tissue from dialysis patients suffering from the effects of aluminum toxicity. By means of this technique aluminum has been shown to be present in high concentration within lysosomes of cerebral neurons of patients with dialysis encephalopathy and along the calci

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https://doi.org/10.1007/978-3-540-88613-6ny Irving, University of Washington, personal communication). In such circumstances, the question of the source of aluminum does not seem difficult. Eight percent of the earth’s crust is aluminum, making it the third most common element. However, most of this metal remains in the rocks or soil as in

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https://doi.org/10.1007/978-3-540-88613-6inum hydroxide [2–4] used to bind phosphate in patients with end stage renal disease, and casein hydrolysate used as the protein source in total parenteral nutrition (TPN) solutions [5] had been primarily implicated. Casein hydrolysate was identified as virtually the only aluminum source on initial

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