Titlebook: Aldol Reactions; Rainer Mahrwald Book 2009 Springer Science+Business Media B.V. 2009 Aldol Additions.Aldol Methodologies.Base.Enzymes.Lewi

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Iain T. Adamson BSc, MSc, AM, PhDl additions high degrees of regio- and diastereoselectivities were measured. C—C bond formation was observed at the sterically more encumbered α-position of the ketones only.. Later on Tanabe and coworkers reported the in situ generation of silyl enol ethers using catalytic amounts of trimethylchlor

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Iain T. Adamson BSc, MSc, AM, PhDenamine formation with a lysine residue of the active site of the enzyme. This step initiates the C—C bond formation process with an aldehyde and subsequent hydrolysis sets the aldol adduct free (Scheme 3.6.1).

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Introduction,n this field of organic chemistry, especially in the last 10 years, there is a need for giving an update and summarizing the existing differing aldol methodologies. This is of particular importance in the field of organocatalysed aldol addition.

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Boron Enolates,l. developed the fundamentals for this transformation.. After these initial reports the attention was drawn to the stereoselective execution of this method. The aldol addition proceeds via a chair-like, six-membered transition state, which is more rigid than those of alkali metal enolates. This is d

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Titanium Enolates,to handle.. First aldol additions of aldehydes to titanium enolates were described by Reetz and coworkers.. The titanium enolates were generated mostly by transmetallation of corresponding lithium enolates with ClTi(O.-Pr). or ClTi(NR.).. Titanium enolates were found to add .-selectively to aldehyde

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Tin Enolates,ere observed in reactions of aldehydes with tin(II) enolates of ketones. In pioneer experiments Mukaiyama and coworkers deployed chiral diamines . and . in enantioselec-tive aldol additions.. The.-configured aldol adducts were isolated with good enantioselectivities. Furthermore, when used with arom

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