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Titlebook: Advances in Multiple Sclerosis and Experimental Demyelinating Diseases; Moses Rodriguez Book 2008 The Editor(s) (if applicable) and The Au

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Pathological Heterogeneity of Idiopathic Central Nervous System Inflammatory Demyelinating Disorderchemical tools to examine the MS lesion microscopically, as well as technological advances in neuroimaging, which permit a dynamic assessment of lesion formation and disease progression. The heterogeneous pathology of MS in relation to stage of lesion activity, phase of disease, and clinical course
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The Multiple Sclerosis Degradome: Enzymatic Cascades in Development and Progression of Central Nervn patterns in MS lesions, sera, and/or cerebrospinal fluid (CSF). Growing evidence exists regarding their mechanistic roles in inflammatory and neurodegenerative aspects of this disease. Proteolytic events participate in demyelination, axon injury, apoptosis, and development of the inflammatory resp
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Genetic Analysis of CNS Remyelination,l role in determining the level of accompanying neurologic disability. While remyelination can be quite robust, in multiple sclerosis it often fails. Understanding and stimulating the remyelination process are therefore important goals in MS research. Remyelination is a complex cellular process that
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Remyelination in Experimental Models of Toxin-Induced Demyelination,y and maintenance of axonal health. It occurs as a spontaneous regenerative response following demyelination in a range of pathologies including traumatic injury as well as primary demyelinating disease such as multiple sclerosis (MS). Experimental models of demyelination based on the use of toxins,
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Neuroimaging of Demyelination and Remyelination Models,ommonly used autoimmune, viral, and toxic models. Because most MS models are induced in rodents with brains and spinal cords of a smaller magnitude than humans, small-animal MRI must accomplish much higher resolution acquisition in order to generate useful data. In this review, we discuss key aspect
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Hormonal Influences in Multiple Sclerosis,fluence inflammation and neuron and glial function is being slowly unraveled. There is increasing evidence that estrogen, progesterone, and testosterone contain immune responses and influence damage repair in the nervous system. Hormones such as prolactin and vitamin D are being explored as immunomo
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