Titlebook: Advanced Patch-Clamp Analysis for Neuroscientists; Alon Korngreen Book 2016 Springer Science+Business Media New York 2016 in-vivo recordin

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J. Tony Pembroke,Michael P. Ryanor cardiac myocytes. Mutations in Na.s are linked to several severe conditions, such as pain syndromes, epilepsy, and cardiac arrhythmias and these ion channels are therefore among the most promising drug targets. The development of Na. modulators is complicated by the intricate gating mechanisms of

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Shereena P. Joy,Chandraraj Krishnaneive and transform this input. This is due largely to their typically submicron size, which has historically rendered them inaccessible for direct recording. However, the advent of electrophysiological patch-clamp and advanced imaging techniques over the past few decades has opened this field of res

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Shereena P. Joy,Chandraraj Krishnanction potentials, and conduct the output signal to the presynaptic terminals. With the establishment of patch-clamp recording techniques in brain slices in combination with high-resolution microscopy, it has now become possible to visually target patch-clamp electrodes to various domains of the axon

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Shereena P. Joy,Chandraraj Krishnanction of complex cortical neuronal circuits, a process requiring analysis of synaptic interconnections and identification of cell types of interconnected neurons, we have developed a simultaneous quadruple-octuple whole-cell recordings technique that allows physiological analysis of synaptic interco

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Biofuels and Food Security in China,al synaptic connections is only possible using paired or multiple recordings from synaptically coupled neurones. No other electrophysiological or optophysiological technique allows a correlated functional and structural characterization of both pre- and postsynaptic neurone, even down to the electro

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