Titlebook: Acute Leukemias VI; Prognostic Factors a T. Büchner,G. Schellong,B. Wörmann Conference proceedings 1997 Springer-Verlag Berlin Heidelberg 1

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https://doi.org/10.1007/978-3-540-32687-8The role of specific structural abnormalities in the definition of subvariants in acute leukemias and estimation of prognosis for individual patients is well known [1,2]. The value of numerical karyotypic characteristics, especially hypo- and hyperdiploidies as important criteria for prognosis in All and AML is also known [3].

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https://doi.org/10.1007/978-3-642-40511-2are closely associated with particular morphologic subtypes of these tumors. Rearrangements involving chromosome band 11q23 are common in acute leukemia, both lymphoblastic and myeloid (monoblastic), and are less common in lymphoma. Although several different genes have been cloned from 11q23 transl

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Protection Against Snow Avalanche Hazardsleukemia carrying a pericentric inversion 16; 56 were de novo AML and 3 were secondary AML after treatment with cytotoxic drugs for a primary tumor. Additional chromosome aberrations were observed in 17 patients (29%). Eight of them showed an additional chromosome 8, 3 an additional chromosome 22. D

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Shiva P. Pudasaini,Kolumban Huttermmunophenotype (CD34+/CD38-) are involved in the leukemogenic process. In 12 patients with AML and in one patient with MDS the identification of (pre)leukemic cells was performed by classical cytogenetics. Highly purified (96-98% purity) cellular subpopulations were generated by fluoresence activate

congenial

Protection Against Snow Avalanche Hazardsomosomes 5, 7, and 11 were found to be most frequently involved in numerical or structural aberrations. Whereas in ANLL chromosomes 5 and 7 predominated, chromosome 11 was found in all groups, but mainly in ALL. The breakpoints of different rearrangements were always located in band 11q23..In 4 of 6

Control-Group

Shiva P. Pudasaini,Kolumban Hutterry rarely as solitary anomaly. Here we report a case of acute nonlymphocytic leukemia (ANLL) after radiochemotherapy for Hodgkin’s disease, with a deletion of chromosome 6 (p21pter). This is the first case of deletion 6p as a solitary chromosomal anormaly reported in therapy-related ANLL. This case

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Shiva P. Pudasaini,Kolumban Hutternvolve deletions of 7q. We applied fluorescent in situ hybridization (FISH) using a chromosome 7 paint and a 7q telomere-specific probe for a better characterization of 7q abnormalities in a series of patients with acute leukemia. Of the six patients studied, five had structural abnormalities of 7q

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Protection Against Snow Avalanche Hazardsg the precise diagnosis and the prognosis of disease. For FAB M6 subtype, many karyotype changes have been described and classified as minor and major karyotype abnormalities (MIKA and MAKA) [1]. Here we report the combination of two clonal chromosome changes in a child with M6 AML.

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Protection Against Snow Avalanche Hazards2 time x 10./leukocytes- 21 x 10./1: blasts 74%, neutrophils 9%, lymphocytes 14%, monocytes 3%. After bone marrow puncture, AML FAB M2 was diagnosed. Cytogenetic analysis of bone marrow showed two clones: 1, 46 XX (20%) and clone 2, 46 XX t(8;21) (q22;q22) and t(l;17) (q21;pl3) (80%). CSF examinatio