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The Development of the Concept of Drug Receptors in the Physiological Research of John Newport Langort Langley (1852–1925) who first proposed a receptor theory for the action of drugs and transmitter substances in the body. In this chapter we discuss how Langley developed, over a period of 30 years and in diverse research contexts, his ideas on the mode of action of drugs and physiological substa

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Receptors and Scientific Pharmacology I: Critics of the Receptor Idea and Alternative Theories of Dpecial case of drug-binding receptors. Despite early resistance to certain aspects of their theories, Langley and Ehrlich were successful in promoting and publicizing their concepts within the scientific communities of physiology, immunology and bacteriology, and the new theories of drug-binding rec

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Quantitative Arguments for the Existence of Drug Receptors and the Development of the Receptor Occuspecific ‘receptive substances’ in cells. When drugs or hormones bound chemically to these substances, the metabolism of the ‘chief substance’ of the cell would be influenced, and thus the cell’s function (for example, secretion in gland cells, contraction in muscle cells) would be changed. In this

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,The Dual Adrenalin Receptor Theory of Raymond P. Ahlquist (1914–83) and its Application in Drug Devwas considered only as one of a number of options available to clarify the problem of drug binding. Consequently, its fate remained uncertain within the scientific community of pharmacologists during the first half of the twentieth century. The most important representatives of the discipline propag

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