Titlebook: Werkstofftechnik für Wirtschaftsingenieure; Bozena Arnold Textbook 20131st edition Springer-Verlag Berlin Heidelberg 2013 Verarbeitungsmet

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Steady-State Pharmacokinetics of Nisoldipine in Patients with Liver Diseaseconcentrations of 1.57 ± 1.00 ng/ml (0.38–3.96 ng/ml) were obtained. Oral clearance of nisoldipine ranged from 49.3 to 3.0 liter/min (median 8.5 liter/min) with the lowest values for patients with liver cirrhosis (3.0 and 4.2 liter/min). Thus, adjustment of the dosage is recommended in patients with impaired liver function.

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Using Change in Local DNA Sequence Complexity as a Pointer to the Mechanism of Mutagenesis in Inheri0 micro-insertions, and 211 indels. The change in complexity was found to be indicative of the type of repeat sequences involved in mediating the deletion/insertion event, which in turn provided pointers as to the possible pathways through which the mutations could have arisen.