| 期刊全称 | Airways Smooth Muscle | | 期刊简称 | Structure, Innervati | | 影响因子2023 | David Raeburn (Department Head),Mark A. Giembycz ( | | 视频video | | | 学科分类 | Respiratory Pharmacology and Pharmacotherapy | | 图书封面 |  | | 影响因子 | Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be incr | | Pindex | Book 1994 |
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发表于 2025-3-21 17:02:20
