Overview: This volume contains the edited transcript of the second Totts Gap Colloquium, held at Totts Gap, Pennsylvania, May 29-31, 1975. The objective of the Colloquium was to bring into focus what is known of pathogenic mechanisms of schizophrenic manifestations. One hope was to differentiate among syndromes that share the fea~ tures of schizophrenia, disorganization of thought and talk, inap propriateness of affect, circumstantiality, withdrawal from social interaction, paranoid ideation, hallucinations, delusions, catelepsy, catatonic excitement or mutism, etc. What is known of the neura
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