RENIN
发表于 2025-3-25 05:36:38
Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities,ally terminating in a quiescent but viable state now known as replicative senescence. These cells show clear and distinctive morphological, physiological and biochemical characteristics. Moreover, the senescent phenotype is associated with a typical gene-expression profile. Similar behaviour has sin
陶瓷
发表于 2025-3-25 08:44:31
Pro-senescence Therapy for Cancer: Time for the Clinic, senescence response, termed pre-mature senescence, driven by DNA-damage, oncogene over-expression or loss of tumour suppressor genes. Recent evidences demonstrate that cellular senescence occurs also in tumours, where it opposes tumour initiation and progression. Senescence cells secrete a variety
易弯曲
发表于 2025-3-25 14:59:03
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有发明天才
发表于 2025-3-25 16:45:29
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涂掉
发表于 2025-3-25 23:00:31
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vitrectomy
发表于 2025-3-26 01:28:01
Endoplasmic Reticulum Stress in Multiple Myeloma: From Molecular Mechanisms to Therapeutic Opportunulation of misfolded proteins in the ER leads to ER stress, which triggers the activation of three well-known pathways including activating inositol requiring kinase 1 (IRE1), the transcription factor activating transcription factor 6 (ATF6), and double stranded RNA-activated protein kinase-like ER
组成
发表于 2025-3-26 06:34:05
Melanomagenic Gene Alterations Viewed from a Redox Perspective: Molecular Mechanisms and Therapeuti, and invasiveness of cancer cells has recently emerged. A large body of experimental and epidemiological research has substantiated the causative involvement of specific genetic alterations in melanomagenesis. Strikingly, some of the proteins encoded by specific genes underlying melanomagenesis (.,
Multiple
发表于 2025-3-26 09:22:29
Targeting Hypoxic Adaptations of Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities, metastasis, and chemoresistance. Given its central role in tumorigenesis, tumour hypoxia is an attractive therapeutic target. There are three main O.-sensing pathways, namely the unfolded protein response (UPR), the target of rapamycin kinase (mTOR), and the hypoxia-inducible factor-1 (HIF-1) pathw
Immobilize
发表于 2025-3-26 13:00:39
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Anthrp
发表于 2025-3-26 17:35:17
At the Crossroads Between Mitochondrial Metabolite Transport and Apoptosis: VDAC1 as an Emerging Caa great majority of cancer types. The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane protein, serves as a mitochondrial gatekeeper, controlling the metabolic and energy cross-talk between mitochondria and the rest of the cell. VDAC1 has also been recognized as a key protei