以烟熏消毒
发表于 2025-3-30 11:06:12
Identification of Time-Dependent CYP Inhibitors Using Human Liver Microsomes (HLM),t in clinically relevant drug-drug interactions (DDIs). Drugs that are time dependent inhibitors (TDIs) of CYPs have been reported to cause severe DDIs, leading to prescription adjustments and, in certain cases, have been withdrawn from the market (Zhou et al., Ther Drug Monit 29:687–710, 2007). Oft
Cpap155
发表于 2025-3-30 15:22:26
CYP Time-Dependent Inhibition (TDI) Using an IC50 Shift Assay with Stable Isotopic Labeled Substratstrates. The assay is performed in a 96-well format and can be fully automated and extended to a 384-well format if desired. Since the IC. shift assay requires parallel paired incubations to obtain two inhibition curves for comparison, the use of stable isotopic labeled probe substrates and non-labe
engender
发表于 2025-3-30 20:35:44
Book 2014Latest editioning formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity ass
Goblet-Cells
发表于 2025-3-31 00:11:33
1557-2153 s and protocols that are lab-tested and successful.Includes .Thoroughly revised and updated, .Optimization in Drug Discovery: In Vitro Methods, Second Edition. presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UD
虚情假意
发表于 2025-3-31 01:48:01
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乱砍
发表于 2025-3-31 07:25:07
Assessment of CYP3A4 Time-Dependent Inhibition in Plated and Suspended Human Hepatocytes,The metabolite 1′-hydroxymidazolam is then quantified by LC/MS/MS. The TDI potential of the test compound may then be evaluated by determining the enzyme activity remaining after each condition. Methods to determine K. and k. values from these data, as well as tips and considerations for robust assay outcomes are also provided.
wall-stress
发表于 2025-3-31 11:54:01
In Situ Single Pass Perfused Rat Intestinal Model, a complete radial mixing model. This model is an effective approach used for selecting drug candidates with a desired BCS classification, which ultimately could improve the success rate in the selection of new chemical entities for eventual clinical use.
critique
发表于 2025-3-31 13:35:02
Drug Partition in Red Blood Cells,rmination of blood-to-plasma ratios at the discovery level of development where species comparisons can be an important determinant in the design and interpretation of some observed pharmacokinetic study results. Methods employing the use of both radiolabeled and cold materials will also be discussed using a variety of analytical tools.
消音器
发表于 2025-3-31 19:47:47
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JOG
发表于 2025-3-31 22:09:26
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