GENRE 发表于 2025-3-28 16:59:49
http://reply.papertrans.cn/71/7033/703247/703247_41.pngHUMP 发表于 2025-3-28 22:12:39
In Vitro CYP/FMO Reaction Phenotyping, drug might be susceptible to changes in its exposure or to cause changes in the exposure of concomitantly administered drugs. The semi-quantitative assessment of the relative contributions of these pathways can provide early insight to the potential for drug-drug interactions or to possible affinit发酵剂 发表于 2025-3-29 00:57:14
Human Pregnane X Receptor (hPXR) Activation Assay in Stable Cell Lines,eractions (DDIs) is a wildly used technique among . assays. Direct assessment of PXR activation is a cell-based assay that requires two major components, the PXR and a reporter gene linked to the promoter and enhancer regions of the CYP3A gene. Because of species differences in the ligand binding re半导体 发表于 2025-3-29 04:22:39
Characterization of Constitutive Androstane Receptor (CAR) Activation,ous hepatic drug-metabolizing enzymes and transporters in response to various xenobiotic exposures. Unlike most prototypical nuclear receptors, however, CAR can be activated . both direct ligand-binding and ligand-independent indirect mechanisms. Moreover, whereas CAR predominantly resides in the cy设施 发表于 2025-3-29 07:21:35
http://reply.papertrans.cn/71/7033/703247/703247_45.pngMOTIF 发表于 2025-3-29 12:58:09
Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators,tructurally diverse synthetic and naturally occurring chemicals. The role of the AhR and its signaling pathway in endogenous physiological functions and its involvement in immune cell development and human diseases has made it a target for development of therapeutic agents. The ability of the AhR toEstimable 发表于 2025-3-29 17:37:49
In Vitro CYP Induction Using Human Hepatocytes,ar receptors (NRs), respectively, is routinely determined during small molecule drug development. Significant CYP induction can result in therapeutic failure from clinical exposure of a compound outside the therapeutic window, if the respective enzymes are responsible for a significant portion of tharistocracy 发表于 2025-3-29 22:57:28
http://reply.papertrans.cn/71/7033/703247/703247_48.pngCLAY 发表于 2025-3-30 02:03:13
Evaluation of Time-Dependent CYP3A4 Inhibition Using Human Hepatocytes, a clinical interaction from pre-clinical TDI data have been lacking. Although more complex prediction algorithms have been developed, the accuracy has still improved little. This suggests alternate methods to collect input data may improve prediction robustness. Historically, human liver microsomesObstreperous 发表于 2025-3-30 04:02:16
http://reply.papertrans.cn/71/7033/703247/703247_50.png