bile648 发表于 2025-3-26 23:41:37

Maria Markowska,L. Mark Kaon­ formiert werden. Ohne das Datenmaterial wären die Planung, Steuerung und Kontrolle des gesamten Unternehmensgeschehens nicht möglich. Die erforderli­ chen Daten werden dabei zum einen in ihrer ursprünglichen Form verwendet, zum anderen müssen sie für die Verwendung zuerst zweckorientiert aufberei

SLUMP 发表于 2025-3-27 03:11:41

Kevin J. Coe,Tatiana Koudriakovan­ formiert werden. Ohne das Datenmaterial wären die Planung, Steuerung und Kontrolle des gesamten Unternehmensgeschehens nicht möglich. Die erforderli­ chen Daten werden dabei zum einen in ihrer ursprünglichen Form verwendet, zum anderen müssen sie für die Verwendung zuerst zweckorientiert aufberei

Etching 发表于 2025-3-27 06:12:17

Carlo Sensenhauser außerhalb des Unternehmens in­ formiert werden. Ohne das Datenmaterial wären die Planung, Steuerung und Kontrolle des gesamten Unternehmensgeschehens nicht möglich. Die erforderli­ chen Daten werden dabei zum einen in ihrer ursprünglichen Form verwendet, zum anderen müssen sie für die Verwendung zu

慌张 发表于 2025-3-27 13:31:06

http://reply.papertrans.cn/71/7033/703247/703247_34.png

Hdl348 发表于 2025-3-27 14:38:35

Assessment of Drug Plasma Protein Binding in Drug Discovery,es because the free drug concentration at the site of action is responsible for the pharmacological activity. This chapter will describe various methods commonly used for the . determination of plasma protein binding including classical equilibrium dialysis (CED), rapid equilibrium dialysis (RED), a

宫殿般 发表于 2025-3-27 18:25:39

Drug Partition in Red Blood Cells,ertain therapeutic compounds have a high degree of affinity for the red blood cell fraction of whole blood and have large RBC-to-plasma concentration ratios. Knowledge of . RBC partitioning of compounds is important to the interpretation and understanding of the compounds pharmacokinetic profile and

palette 发表于 2025-3-27 23:25:47

Permeability Assessment Using 5-day Cultured Caco-2 Cell Monolayers,ormat. The 5-day accelerated Caco-2 assay is based on previous literature protocols where inserts are coated with collagen protein and the culturing cell media contains sodium butyrate to modify differentiation and growth properties of the cell line. Protocol conditions for the accelerated 5 day Cac

Nausea 发表于 2025-3-28 02:29:53

In Situ Single Pass Perfused Rat Intestinal Model, System (BCS) classification. BCS classification of drug candidates can influence the drug development path, specifically around formulation development, and the potential route used for drug administration. The . single pass perfused rat intestinal model has been shown to be highly predictive of hu

唠叨 发表于 2025-3-28 09:29:54

Metabolic Stability Assessed by Liver Microsomes and Hepatocytes,t undergo extensive metabolism. Drug metabolism can be assessed in a variety of . test systems, including microsomes, cytosol or S9 fractions, hepatocytes (suspension or plated), and isolated liver slices. In drug discovery, metabolic stability is typically determined by measuring the depletion of t

作茧自缚 发表于 2025-3-28 13:53:30

Metabolic Assessment in Alamethicin-Activated Liver Microsomes: Co-activating CYPs and UGTs,lic pathways in microsomes. Alamethicin, a pore-forming peptide, was used to activate UGTs in human liver microsomes. An alamethicin-microsomal activated system in which both CYPs and UGTs were active can be used for studies of metabolic stability and . metabolite profiling. For compounds with minor
页: 1 2 3 [4] 5 6 7
查看完整版本: Titlebook: Optimization in Drug Discovery; In Vitro Methods Gary W. Caldwell,Zhengyin Yan Book 2014Latest edition Springer Science+Business Media New