善于
发表于 2025-3-23 10:59:08
Affinity Measurement of Non-covalent Interactions of the Covalent KRAS G12C GDP Inhibitor MRTX849 tof molecular interactions but also association and dissociation rates of such interactions. In this chapter, we describe a general method to measure the affinity of a small molecule drug, MRTX849, to GDP bound HRAS, KRAS, and NRAS.
小鹿
发表于 2025-3-23 14:43:00
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perjury
发表于 2025-3-23 21:57:57
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Slit-Lamp
发表于 2025-3-24 01:54:17
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Nausea
发表于 2025-3-24 03:25:09
KRAS4b:RAF-1 Homogenous Time-Resolved Fluorescence Resonance Energy Transfer Assay for Drug Discovees compared to traditional assay techniques. In this chapter, we describe an HTRF protein-protein interaction (PPI) assay for the KRAS4b G-domain in the GppNHp-bound state and the RAF-1-RBD currently used for drug screens. Application of this assay contributes to the identification of lead compounds targeting the GTP-bound active state of K-RAS.
Hiatal-Hernia
发表于 2025-3-24 08:11:58
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Amplify
发表于 2025-3-24 14:33:50
978-1-0716-3824-8Leios Biomedical Research, Inc. 2024
MIME
发表于 2025-3-24 18:33:57
KRAS978-1-0716-3822-4Series ISSN 1064-3745 Series E-ISSN 1940-6029
模范
发表于 2025-3-24 20:08:11
Andrew G. Stephen,Dominic EspositoIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
有斑点
发表于 2025-3-25 01:23:34
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