得意人 发表于 2025-3-28 18:20:46
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From the Atmosphere to the Mitochondrion: The Oxygen Cascade mitochondria, and the means whereby this delivery is regulated and optimized for efficiency and the “survival” of the organism as a whole. This occurs in four sequential steps comprising 1. mass transport exchange of air into and out of the alveolar spaces; 2. . exchange of oxygen and carbon dioxid北极人 发表于 2025-3-29 01:15:42
Pathophysiology of Hemorrhagic Shock and Resuscitation derangement of the normal oxygen supply–demand balance, accumulation of the byproducts of anaerobic metabolism, and dysfunction of one or more organ system. In the case of massive hemorrhage, shock is due specifically to impaired oxygen delivery (VO.) secondary to both hypovolemia and anemia. Resto相同 发表于 2025-3-29 03:52:21
Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhagerationale for allogeneic red cell transfusion in surgical and traumatic hemorrhage in a hospital setting. A large number of patients have now been enrolled in clinical trials. This experience provides high quality evidence to inform the transfusion decision. A restrictive transfusion has been establ青春期 发表于 2025-3-29 08:00:08
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Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trialsues, mainly for treatment of shock due to blood loss. These products are being developed in order to treat blood loss when red blood cells are not available, as may occur on the battlefield or in civilian life when trauma occurs.semiskilled 发表于 2025-3-29 17:08:45
http://reply.papertrans.cn/43/4257/425606/425606_47.pngInclement 发表于 2025-3-29 20:43:40
Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structuredevelopment of Hb-based oxygen carriers (HBOCs). The physiological significance of the RBC structure is undergoing reconsideration. Fundamentally, excessive native Hb molecules are toxic, but encapsulation can shield this toxic effect. Cellular type HBOCs of various kinds are developed using liposom脱落 发表于 2025-3-30 01:39:50
Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injurr . expression system and purified. They were used as resuscitation fluids in our unique mouse model of traumatic brain injury (TBI) combined with severe hemorrhagic shock (HS). A sulfhydryl group was introduced onto the surface of the α-subunits of rHb A by substituting Asn78 with cysteine. The rHb敲诈 发表于 2025-3-30 06:07:57
Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturess and large production costs have hindered the progress in its development and, subsequently, its advancement to practical applications. However, we have been persistently developing LEH as an analogue of red blood cells (RBCs) for its use as AOCs, and to this end we have constructed a Good Manufa