Synchronism 发表于 2025-3-28 17:44:50
Crystal Structures of Drug-Metabolizing CYPsf their crystallographic protein structures. Fortunately, despite low sequence similarity between different families of drug-metabolizing CYPs, there exists a high degree of structural homology within the superfamily. This similarity in the protein fold allows for a direct comparison of the structurHyperalgesia 发表于 2025-3-28 22:12:49
The Structure and Mechanism of Drug Transportershey translocate drugs, as well as endogenous molecules and toxins, across membranes using ATP hydrolysis, or ion/concentration gradients. In general, drug transporters are expressed ubiquitously, but they function in drug disposition by being concentrated in tissues such as the intestine, the kidneytinnitus 发表于 2025-3-28 23:37:47
Enzyme Kinetics of Oxidative Metabolism—Cytochromes P450otics). The versatility of these enzymes results in some unusual kinetic properties, stemming from the simultaneous interaction of multiple substrates with the CYP active site. Often, the CYPs display kinetics that deviate from standard hyperbolic saturation or inhibition kinetics. Non-Michaelis-Men嬉耍 发表于 2025-3-29 04:19:43
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