断岩
发表于 2025-3-21 19:39:22
书目名称DNA Topoisomerases in Cancer Therapy影响因子(影响力)<br> http://figure.impactfactor.cn/if/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy影响因子(影响力)学科排名<br> http://figure.impactfactor.cn/ifr/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy网络公开度<br> http://figure.impactfactor.cn/at/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy网络公开度学科排名<br> http://figure.impactfactor.cn/atr/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy被引频次<br> http://figure.impactfactor.cn/tc/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy被引频次学科排名<br> http://figure.impactfactor.cn/tcr/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy年度引用<br> http://figure.impactfactor.cn/ii/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy年度引用学科排名<br> http://figure.impactfactor.cn/iir/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy读者反馈<br> http://figure.impactfactor.cn/5y/?ISSN=BK0260204<br><br> <br><br>书目名称DNA Topoisomerases in Cancer Therapy读者反馈学科排名<br> http://figure.impactfactor.cn/5yr/?ISSN=BK0260204<br><br> <br><br>
傲慢物
发表于 2025-3-21 23:20:21
http://reply.papertrans.cn/27/2603/260204/260204_2.png
绅士
发表于 2025-3-22 04:13:41
http://reply.papertrans.cn/27/2603/260204/260204_3.png
foliage
发表于 2025-3-22 07:23:46
Degradation of topoisomerase cleavable complexes,Pl, hTOP2a and hTOP2β, have been demonstrated to be important molecular targets for anticancer drugs (Liu, 1989; Wang, 1985; Wang, 1996; Chen and Liu, 1994; Hsiang and Liu, 1988; Zhang ., 2001; Li and Liu, 2001; Mao .., 1999; Nitiss and Wang, 1996; Kingma and Oscheroff, 1998).
消灭
发表于 2025-3-22 08:50:37
Yeast as a model system in the analysis of DNA topoisomerase I poisons,anied by the formation of a covalent Top1-DNA intermediate, in which the active site tyrosine of Top1 is linked to a 3’ phosphoryl DNA end. This distinguishes type IB enzymes from other DNA topoisomerases, which form a 5’ phospho-tyrosyl linkage.
不来
发表于 2025-3-22 16:12:25
Approaches to Artificial Intelligence,se II targeting agents act against the enzyme, what events following topoisomerase II inhibition are important for cytotoxicity, and how cells can elaborate resistance to topoisomerase II targeting agents.
不来
发表于 2025-3-22 17:59:35
Understanding the action of drugs targeting TOP2: ,,se II targeting agents act against the enzyme, what events following topoisomerase II inhibition are important for cytotoxicity, and how cells can elaborate resistance to topoisomerase II targeting agents.
训诫
发表于 2025-3-22 22:43:00
at Harvard University, contributed an article: `Reflections .In the mid 80‘s type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investiga
flaunt
发表于 2025-3-23 02:08:04
https://doi.org/10.1007/978-3-031-08743-1ing of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin.
脆弱带来
发表于 2025-3-23 08:31:59
Gunay Kazimzade,Yasmin Patzer,Niels Pinkwartaction. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin, and stimulated the search of non-camptothecin inhibitors (5, 6).