Prophylaxis
发表于 2025-3-23 13:15:19
Mechanisms of topoisomerase I inhibition by anticancer drugs,ing of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin.
绊住
发表于 2025-3-23 15:58:15
Development of new topoisomerase I-targeting compounds as candidate anticancer drugs,action. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin, and stimulated the search of non-camptothecin inhibitors (5, 6).
synchronous
发表于 2025-3-23 21:51:54
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一小块
发表于 2025-3-23 22:25:33
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ULCER
发表于 2025-3-24 04:21:38
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POLYP
发表于 2025-3-24 08:56:11
ML Models: Food Security and Climate Changearrival as an assistant professor of chemistry. The country in general, and Berkeley in particular, was under the dark shadow of the Vietnam War. There were frequent demonstrations on campus, and once the campus was teargassed by a helicopter. For weeks a “stink bomb” left a repugnant smell in our e
Alveolar-Bone
发表于 2025-3-24 10:54:09
https://doi.org/10.1007/978-3-031-08743-1 salt of camptothecin was found to be clinically active but its use was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-
BRAVE
发表于 2025-3-24 17:58:01
https://doi.org/10.1007/978-3-031-08743-1ess and is required for proper chromosomal structure and segregation. The enzyme unknots and untangles DNA by passing an intact helix through a transient double-stranded break that it generates in a separate DNA segment. Beyond its physiological functions, topoisomerase II is the target for some of
细胞学
发表于 2025-3-24 19:31:14
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摇曳的微光
发表于 2025-3-25 00:36:55
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