感情
发表于 2025-3-23 12:23:17
Topoisomerase II Inhibitors: Chemical Biology, etoposide are FDA approved for the treatment of both leukemias and solid tumors. Most clinically active drugs targeting Top2 lead to elevated levels of covalent Top2-cleaved DNA complexes and exert their antitumor effect through enzyme-mediated DNA damage. Drugs targeting Top2 are accompanied by su
轻打
发表于 2025-3-23 14:31:20
Topoisomerase I Inhibitors: Current Use and Prospects,h other agents have ensured their clinical role. c has been part of drug regimens for ovarian cancer, small cell lung cancer (SCLC), and cancer of the uterine cervix; it has also been used as a radiosensitizer in non-small cell lung cancer (NSCLC). Irinotecan was the second drug with activity in col
硬化
发表于 2025-3-23 20:51:01
Topoisomerase II Inhibitors: Current Use and Prospects,because of their long successful track record, provide an element of comfort for treating physicians. Contained within this larger category are the epipodophyllotoxins (VP-16, or etoposide; and VM-26, or teniposide), anthracyclines (doxorubicin, or adriamycin; daunorubicin, or daunomycin; idarubicin
Dictation
发表于 2025-3-23 22:46:20
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政府
发表于 2025-3-24 05:53:46
Mechanisms Regulating Cellular Responses to DNA Topoisomerase I-Targeted Agents,nscription, and recombination. The enzyme clamps around duplex DNA and forms a transient 3′ phosphotyrosyl linkage with a single DNA end. This covalent intermediate is the cellular target of the camptothecin class of chemotherapeutics, which at clinically relevant concentrations induces DNA replicat
Ondines-curse
发表于 2025-3-24 07:05:46
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可商量
发表于 2025-3-24 12:13:17
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Cursory
发表于 2025-3-24 16:54:55
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租约
发表于 2025-3-24 20:45:41
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judicial
发表于 2025-3-25 02:47:06
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