staging 发表于 2025-3-30 08:49:39
DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replicationof these origins is regulated by .-acting sequences and factors that may interact with them. Competition for limiting initiation factors also could regulate the order of origin firing in yeasts. In higher eukaryotes, replication timing may be regulated on a larger genome scale. These so-called repliIncorruptible 发表于 2025-3-30 14:43:08
http://reply.papertrans.cn/27/2602/260193/260193_52.png耕种 发表于 2025-3-30 18:24:56
Regulation of Recombination by Chromatin influences on DNA and its metabolism. Due to its compactness, chromatin generally represses all DNA-templated reactions by preventing DNA-processing proteins from accessing to and/or functioning at their target sites. On the contrary, there are many cases in which condensed chromatin rather facilitinfelicitous 发表于 2025-3-30 21:57:15
Homologous Recombination During Meiosisand repair of developmentally programmed DNA double-strand breaks (DSBs). Cytotoxic lesions such as DSBs are hazardous, potentially mutagenic events that can compromise cellular function. However, during meiosis DSBs are required to establish physical connections between homologous maternal and paterecede 发表于 2025-3-31 03:22:40
DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repairdehyde metabolites or environmental genotoxins such as radiation and chemicals. Unrepaired DNA damage interferes with essential DNA transactions, such as replication and transcription, and eventually gives rise to the alteration of genetic information. Because genomic instability can cause cell deat