dowagers-hump 发表于 2025-3-25 04:17:57
https://doi.org/10.1007/978-1-4613-2261-0 influences on DNA and its metabolism. Due to its compactness, chromatin generally represses all DNA-templated reactions by preventing DNA-processing proteins from accessing to and/or functioning at their target sites. On the contrary, there are many cases in which condensed chromatin rather facilitEstrogen 发表于 2025-3-25 08:19:04
https://doi.org/10.1007/978-1-4613-2261-0and repair of developmentally programmed DNA double-strand breaks (DSBs). Cytotoxic lesions such as DSBs are hazardous, potentially mutagenic events that can compromise cellular function. However, during meiosis DSBs are required to establish physical connections between homologous maternal and pate突变 发表于 2025-3-25 11:40:45
https://doi.org/10.1007/978-1-4613-2261-0dehyde metabolites or environmental genotoxins such as radiation and chemicals. Unrepaired DNA damage interferes with essential DNA transactions, such as replication and transcription, and eventually gives rise to the alteration of genetic information. Because genomic instability can cause cell deatOptic-Disk 发表于 2025-3-25 19:42:17
https://doi.org/10.1007/978-1-4613-2261-0 cross-link (ICL) repair. In this chapter we summarize our current understanding of the function of the FA genes, the mechanism for FA pathway activation, and the processes of ICL repair in the cell. In addition, we will highlight recent evidence that implicates endogenous aldehydes in creating genoConserve 发表于 2025-3-25 21:52:41
http://reply.papertrans.cn/27/2602/260193/260193_25.png案发地点 发表于 2025-3-26 03:45:33
https://doi.org/10.1007/978-1-4613-2261-0ile sites” where DNA damage occurs more frequently than in other regions. In such regions, DNA replication is inhibited and DNA double-strand breaks are induced. Repetitive sequences easily form DNA secondary structures, and during repair of double-strand breaks, a broken end may recombine with a re眼界 发表于 2025-3-26 04:48:29
http://reply.papertrans.cn/27/2602/260193/260193_27.pngFulminate 发表于 2025-3-26 11:44:34
https://doi.org/10.1007/978-1-4613-2261-0s: homologous recombination (HR) and nonhomologous end-joining (NHEJ). HR is the main repair mode for replication-associated DSBs, while NHEJ deals with most other breaks, especially during the G0/G1 phase of the cell cycle. Characterization of the core NHEJ machinery over the past 20 years has been解冻 发表于 2025-3-26 13:03:32
http://reply.papertrans.cn/27/2602/260193/260193_29.png牙齿 发表于 2025-3-26 17:31:11
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