卡死偷电 发表于 2025-3-23 12:22:12
5-Fluorouracil Metabolizing Enzymes,es, and has single-agent activity in colorectal cancer. 5-FU itself is inactive and requires intracellular conversion to form cytotoxic nucleotides (.). Several cellular targets for fluoropyrimidines have been well-characterized, including inhibition of thymidylate synthase (TS) by fluorodeoxyuridinLUMEN 发表于 2025-3-23 16:45:05
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Measurement of Drug-Induced DNA Interstrand Crosslinking Using the Single-Cell Gel Electrophoresis aematological malignancies. Many commonly used clinical agents, such as members of the nitrogen mustard, chloroethylnitrosourea, dimethane-sulphonate and platinum classes, are bifunctional. DNA interstrand crosslinks (ISC) formed in cells are clearly critical cytotoxic lesions and the formation of D同义联想法 发表于 2025-3-24 03:27:02
PCR Analysis of Microsatellite Instability,phic nature have been widely utilized as genetic markers (.). They consist of a repeating unit of 1–5 base pairs, averaging 25–60 bases in length, and are commonly found in the form d(CA)n:d(GT)n (.). It has been estimated that there are approximately 100,000 CA/GT repeat sequences in the human genoBUOY 发表于 2025-3-24 09:04:38
,,-Alkylguanine-DNA Alkyltransferase Assay,diated . alkylation at the ..position of guanine in DNA (.–.). Repair of such adducts can be mediated by ..-alkylguanine-DNA alkyltransferase (ATase) (.,.). Both pro- and eukaryote ATases transfer alkyl groups from the ..-position of guanine in alkylated DNA (or from other low molecular weight subst助记 发表于 2025-3-24 14:17:18
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