含沙射影
发表于 2025-3-23 13:34:29
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Keratin
发表于 2025-3-23 15:02:31
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effrontery
发表于 2025-3-23 20:56:05
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Encephalitis
发表于 2025-3-23 23:32:46
Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact on Nucleosome Dycture. Lysine succinylation is a recently discovered PTM that plays critical roles in metabolism, epigenetic signaling, and is correlated with several diseases. One significant challenge in studying the effects of this modification on nucleosome dynamics is to obtain site-specifically modified histo
打算
发表于 2025-3-24 02:33:08
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额外的事
发表于 2025-3-24 10:27:40
Sulfonium-Tethered Peptide,a series of methods including CIH, TD coupling, Met-Met, and Cys-Met bis-alkylation strategy to switch peptides’ secondary structure and enhance their stability and cellular uptake. Here we focus on the peptide macrocyclization method of Met-Met and Cys-Met bis-alkylation strategy to generate more s
QUAIL
发表于 2025-3-24 11:08:13
PAL-Mediated Ligation for Protein and Cell-Surface Modification,ficiency and mild aqueous reaction conditions, these ligases have emerged as powerful biotechnological tools for protein manipulation in recent years. PALs are enzymes of the asparaginyl endopeptidase (AEP) superfamily but have predominant transpeptidase activity as opposed to typical AEPs which are
现任者
发表于 2025-3-24 16:11:41
Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation,forms). The study of glycosylation is significantly impeded because of the heterogeneous nature of glycoproteins. To overcome this challenge, we developed and optimized a glycoform library-based strategy to investigate the role of protein glycosylation. In this strategy, chemical synthesis was used
Legion
发表于 2025-3-24 23:01:15
A Selenium-based Cysteine Surrogate for Protein Chemical Synthesis,medium. SetCys does not interfere with the native chemical ligation reaction under mild reducing conditions, that is in the absence of tris(2-carboxyethyl)phosphine (TCEP). In contrast, subjecting SetCys to TCEP results in the spontaneous loss of its .-selenoethyl appendage and thus to its conversio
学术讨论会
发表于 2025-3-24 23:41:35
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