decode
发表于 2025-3-28 14:43:59
Structural Requirements for Cannabinoid Receptor Probes, families of endogenous cannabinergic ligands represented by arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-AG), have opened new horizons in this newly discovered field of biology. Furthermore, a considerable number of cannabinoid analogs belonging to structurally diverse classe
deactivate
发表于 2025-3-28 22:01:08
,Cannabinoid Receptors and Their Ligands: Ligand—Ligand and Ligand—Receptor Modeling Approaches,tructural classes of agonists that bind to both receptors, have been identified. An extensive amount of structure-activity relationship information (SAR) has been developed for agonists and antagonists that bind at CB., while the SAR of CB. ligands is only now emerging in the literature. This chapte
牲畜栏
发表于 2025-3-29 01:58:25
The Phylogenetic Distribution and Evolutionary Origins of Endocannabinoid Signalling,ogenous ligands for these receptors and enzymes involved in the biosynthesis and inactivation of anandamide (e.g. NAPE-PLD, FAAH) and 2-AG (e.g. DAG lipase, MGL). In this review we examine the occurrence of these molecules in non-mammalian organisms (
morale
发表于 2025-3-29 06:10:45
Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System, protein-coupled receptor has a characteristic distribution in the nervous system: It is particularly enriched in cortex, hippocampus, amygdala, basal ganglia outflow tracts, and cerebellum—a distribution that corresponds to the most prominent behavioral effects of cannabis. In addition, this distri
VALID
发表于 2025-3-29 07:35:47
Effects of Cannabinoids on Neurotransmission,d in axon terminals, and its activation leads to inhibition of transmitter release. The consequence is inhibition of neurotransmission via a presynaptic mechanism. Inhibition of glutamatergic, GABAergic, glycinergic, cholinergic, noradrenergic and serotonergic neurotransmission has been observed in
发源
发表于 2025-3-29 13:52:07
Retrograde Signalling by Endocannabinoids,noids), as well as mechanisms for their synthesis, membrane transport and metabolism. Within the brain the marijuana constituent . .-tetrahydrocannabinol (THC) produces its pharmacological actions by acting on cannabinoid CB. receptors. THC modulates neuronal excitability by inhibiting synaptic tran
GREG
发表于 2025-3-29 16:42:12
Effects on the Immune System,d in vitro. Two modes of action by which .9-tetrahydrocannabinol (THC) and other cannabinoids affect immune responses have been proposed. First, cannabinoids may signal through the cannabinoid receptors CB. and CB.. Second, at sites of direct exposure to high concentrations of cannabinoids, such as
讨人喜欢
发表于 2025-3-29 21:05:16
Imaging of the Brain Cannabinoid System,an be imaged directly with autoradiography in brain slices using radiolabeled cannabinoid receptor ligands. In addition, the effects of pharmacologic doses of unlabeled cannabinoid drugs can be autoradiographically imaged using indicators of blood flow or indicators of metabolism such as glucose ana
dowagers-hump
发表于 2025-3-29 23:56:57
http://reply.papertrans.cn/23/2214/221310/221310_49.png
Venules
发表于 2025-3-30 05:21:01
http://reply.papertrans.cn/23/2214/221310/221310_50.png