男学院 发表于 2025-3-28 15:56:53
Milestones in Drug Therapyhttp://image.papertrans.cn/b/image/164936.jpgpulse-pressure 发表于 2025-3-28 22:49:43
https://doi.org/10.1007/978-3-642-80732-9 execution of voluntary motor action. Although the course of the illness varies greatly between individuals, the characteristic time-course includes episodes of florid illness superimposed upon a level of chronic disability. The degree of chronic disability ranges from a relatively mild reduction in知道 发表于 2025-3-28 23:57:18
Jochen Ludewig,Martin Glinz,Hans Matheischotic drugs that had been available for some three decades or more, most commonly perphenazine and haloperidol, with an additional 2% receiving loxapine and 13% receiving clozapine [.]. Since the identification in the 1950s of chlorpromazine as the archetype antipsychotic, a profound advance that h积习难改 发表于 2025-3-29 03:19:32
https://doi.org/10.1007/978-3-642-70639-4n identified. The main reason for this, apart from the difficulties in diagnosis (see Liddle, this volume), is the limited accessibility of the human brain. Until about 20 years ago, the investigation of the brains of patients was limited to.analysis. This technique (with a high spatial resolution)Neolithic 发表于 2025-3-29 11:15:24
Jochen Ludewig,Martin Glinz,Hans Matheishe most considered are the dopaminergic [.], the serotonergic (5-hydroxytryptamine, 5-HT) [..] and the glutamatergic systems [.]. The hypotheses essentially emerged from clinical observations with drugs, whose properties became well-documented in pharmacological and biochemical studies. Today’s know高度 发表于 2025-3-29 11:29:52
https://doi.org/10.1007/978-3-642-70639-4fficacy, the incidence of side-effects (especially the extrapyramidal side-effects) differs between individual drugs. This has already been known for a long time, but the earlier studies were largely overlooked. Among the earlier papers were a number of clinical studies comparing several phenothiaziBOOR 发表于 2025-3-29 16:36:50
https://doi.org/10.1007/978-94-6091-982-4of these compounds. In the early times of the dopamine (DA) hypothesis of schizophrenia animal models were designed to detect compounds which blocked the behavioural effects of high doses of dopaminergic drugs (e.g. amphetamine-, apomorphine-and methylphenidate-induced stereotyped behaviour). When.rcajole 发表于 2025-3-29 21:42:36
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