Devastate 发表于 2025-3-26 22:42:30
Animal models for schizophrenia: an introduction. Moreover, most patients suffering from schizophrenia acquire the disease early in life (between 18 and 30 years) and may live well into their sixties or seventies. Even if, in.studies, brain abnormalities are found, it is virtually impossible to determine whether these disturbances are related toFoolproof 发表于 2025-3-27 02:35:22
http://reply.papertrans.cn/17/1650/164936/164936_32.png罐里有戒指 发表于 2025-3-27 05:30:29
Regional selectivity of antipsychotic drugst necessarily had to induce extrapyramidal side-effects [.-.], see also Naber et al., this volume. This drugs seems to be almost completely free of extrapyramidal side-effects, including tardive dyskinesia.毁坏 发表于 2025-3-27 10:45:09
Screening models for antipsychotic drugsing antipsychotic activity. However, these compounds also induced catalepsy in rodents, a model with close symptom analogy of Parkinsonism in humans. This example illustrates the inherent problem using these models in drug discovery, since they pick up compounds which have putative antipsychotic actcompanion 发表于 2025-3-27 16:02:09
Clozapine: the first atypical antipsychoticgranulocytosis under clozapine treatment and eight of them died [.]. In many countries clozapine was withdrawn from the market, while in the German speaking countries, due to the intervention of several renowned psychiatrists, it was not withdrawn and since then is prescribed under precautionary res磨坊 发表于 2025-3-27 19:44:03
http://reply.papertrans.cn/17/1650/164936/164936_36.png心神不宁 发表于 2025-3-28 00:50:13
2296-6056 amidal) side-effects were the most troublesome. Especially the tardive dyskinesia, which occurred in about 15 to 20% of the patients after pro longed treatment978-3-0348-9571-2978-3-0348-8448-8Series ISSN 2296-6056 Series E-ISSN 2296-6064Capture 发表于 2025-3-28 05:08:55
https://doi.org/10.1007/978-3-0348-8448-8dopamine; research; schizophrenia; serotonin; therapy朴素 发表于 2025-3-28 09:23:12
http://reply.papertrans.cn/17/1650/164936/164936_39.png红肿 发表于 2025-3-28 11:20:36
Atypical Antipsychotics978-3-0348-8448-8Series ISSN 2296-6056 Series E-ISSN 2296-6064