Employee
发表于 2025-3-25 06:01:19
Doxorubicin Conjugates for Selective Delivery to Tumors, tumor site while releasing the cytotoxic drug..Among immuno-conjugates representing a widely studied class of doxorubicin derivatives,the clinical development of cBR96-Dox, undoubtedly the most quintessential derivative, was discontinueddue to severe secondary effects. More potent cBR-96 analogues
表状态
发表于 2025-3-25 11:10:55
,Anthracycline–Formaldehyde Conjugates and Their Targeted Prodrugs,raquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stress and drug metabolites. An intermediate in reductive glycosidiccleavage is a quinone methide, once proposed as an alkylating agent of DNA. Subsequent research nowimplicates formaldehyde as a mediator
Grating
发表于 2025-3-25 12:06:28
http://reply.papertrans.cn/16/1583/158257/158257_23.png
incarcerate
发表于 2025-3-25 17:45:38
Nemorubicin,armitalia CarloErba Research Center in Italy. The idea was to develop doxorubicin analogues able to circumvent the emergenceof chemoresistance, in particular the multi-drug resistance. The drug was reported to be active in vitroagainst both murine and human tumor cells resistant to doxorubicin. Simi
Comprise
发表于 2025-3-25 22:24:45
Anthracycline Chemistry and Biology II978-3-540-75813-6Series ISSN 0340-1022 Series E-ISSN 1436-5049
caldron
发表于 2025-3-26 02:07:30
http://reply.papertrans.cn/16/1583/158257/158257_26.png
groggy
发表于 2025-3-26 06:38:01
Karsten KrohnSeries presents critical reviews of the present position and future trends in modern chemical research.Short and concise reports on chemistry, each written by the world renowned experts. Still valid a
心胸狭窄
发表于 2025-3-26 08:43:04
http://reply.papertrans.cn/16/1583/158257/158257_28.png
Simulate
发表于 2025-3-26 15:00:49
http://reply.papertrans.cn/16/1583/158257/158257_29.png
Thyroxine
发表于 2025-3-26 17:08:47
978-3-642-09495-8Springer-Verlag Berlin Heidelberg 2008