expansive
发表于 2025-3-25 05:01:24
Non-protected Synthesis of Oligonucleotides–N bond cleavage using 6-nitro-HOBt is more than 99% in the RNA synthesis without base protection. In this review, we summarize the .-selective phosphorylation in DNA and RNA synthesis without base protection and the synthesis of modified oligonucleotides having alkaline-labile functional groups using these new methods.
Indebted
发表于 2025-3-25 09:40:58
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荣幸
发表于 2025-3-25 14:26:07
Book 2018tic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of
可以任性
发表于 2025-3-25 18:29:22
Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modifiede physicochemical properties of thio-modified bases and the methods for the syntheses of 2-thiouridine and 2-thiothymidine are described. In addition, the solid-phase synthesis of oligonucleotides incorporating these thio-nucleosides is described.
Accolade
发表于 2025-3-25 20:58:18
Site-Specific Modification of Nucleobases in Oligonucleotides, the site-specific modifications focusing on nucleobases within oligonucleotides are summarized. Moreover, as an experimental example of site-specific modification of an oligonucleotide, the preparation of .,.-disubstituted cytosine derivatives using reaction of 4-triazolylpyrimidin-2-one nucleobase with various secondary amines is demonstrated.
demote
发表于 2025-3-26 03:11:52
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Cholesterol
发表于 2025-3-26 08:20:27
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MIRE
发表于 2025-3-26 11:04:45
Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modiith their complementary nucleic acid within a few seconds of photoirradiation are examined. The details of the synthetic method, properties and the applications for regulating gene expression in cells are discussed.
Affirm
发表于 2025-3-26 15:06:09
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都相信我的话
发表于 2025-3-26 17:31:45
and inspire fresh ideas in nucleic acid chemistry.Meets the .This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous