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Translational Molecular Approaches in Substance Abuse Research,anslational research strategies that are applied in the pursuit of new and more effective therapeutics for substance use disorder (SUD). The complex, multidimensional nature of psychiatric disorders like SUD presents difficult challenges to investigators. While animal models are critical for outlini竞选运动 发表于 2025-3-22 04:10:17
Small Molecule Neuropeptide S and Melanocortin 4 Receptor Ligands as Potential Treatments for Subst (SUDs) to date have been mostly ineffective other than substitution-like therapeutics. Two such targets are the peptide G-protein-coupled receptors neuropeptide S (NPS) and melanocortin 4 (MC4). Preclinical evidence suggests that antagonists, inverse agonists, or negative allosteric modulators of tPatrimony 发表于 2025-3-22 07:15:22
Emerging Insights into Mu Opioid Pharmacology,ug development efforts for over a 100 years have resulted in a large variety of opioid analgesics used in the clinic, but all of them continue to exhibit the side effects, especially respiratory depression, that have long plagued the use of morphine. The recent explosion in fatalities resulting from一再困扰 发表于 2025-3-22 09:36:37
Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors,e detrimental to individuals as well as society and have contributed to the ongoing opioid crisis. The dramatic escalation in overdose deaths over the last 15 years was initially driven by abuse of prescription opioids, although abuse of heroin, fentanyl, and fentanyl analogs has been increasing, la我就不公正 发表于 2025-3-22 14:08:41
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Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder,nt learning processes which develop after repeated exposure to drugs of abuse. At the core of this phenotype is the persistence of symptoms, such as craving and relapse to drug seeking, long after the cessation of drug use. The neural basis of these behavioral changes has been linked to dysfunction描绘 发表于 2025-3-23 06:36:44
Molecular Mechanisms of Amphetamines,ing these effects are contained within the amphetamine structure. In the first part of this review, the interaction of amphetamine with the dopamine transporter (DAT), crucially involved in its behavioral effects, is covered, as well as the role of dopamine synthesis, the vesicular monoamine transpo