GENUS 发表于 2025-3-25 04:33:01

Interim Analyses,pursued appropriately by the investigators and to look at any difficulties, e.g., those with patient and/or doctor compliance, and to see whether there is any need for protocol alterations.. “Looking at the data” for such purposes should, however, be done carefully. In this chapter we will discuss questions such as:

Indolent 发表于 2025-3-25 11:09:01

Book 2000ations had been uncontrolled. Initially,trials frequently did not confirm the hypotheses to be tested. Thisphenomenon was attributed to low sensitivity due to small samples, aswell as inappropriate hypotheses based on biased prior trials.Additional flaws were recognized and, subsequently, were bette

江湖郎中 发表于 2025-3-25 12:15:16

Hypotheses, Data, Stratification,ve way of determining the relative efficacy and toxicity of new drug therapies. This course is mainly involved in the methods of prospective randomized clinical trials of new drugs. Other methods for assessment including open-evaluation-studies, cohort- and case-control studies, although sometimes u

镶嵌细工 发表于 2025-3-25 18:08:32

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恶臭 发表于 2025-3-25 21:58:47

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直言不讳 发表于 2025-3-26 02:27:58

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抛媚眼 发表于 2025-3-26 07:45:07

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反对 发表于 2025-3-26 10:56:42

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aplomb 发表于 2025-3-26 16:14:53

Meta-Analysis,uently have to be transformed into binary data for the purpose of comparibility; bad studies may be included; coverage may be limited; data may not be homogeneous; failure to relate data to hypotheses may obscure discrepancies. In spite of these well-recognized flaws, the method of meta-analysis is

helper-T-cells 发表于 2025-3-26 19:00:00

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查看完整版本: Titlebook: Statistics Applied to Clinical Trials; Ton J. Cleophas,Aeilko H. Zwinderman,Toine F. Cleo Book 2000 Springer Science+Business Media B.V. 2