LUMEN
发表于 2025-3-27 00:08:25
Dihydroceramide: Sphinganine Δ4-Desaturase and C4-Hydroxylaseeramide has attracted attention because it is a signaling molecule involved in apoptosis. The genes for .-acylsphinganine, sphinganine ω4-desaturase and C4-hydroxylase, are responsible for the biosynthesis of ceramide and dihydroceramide. These genes were identified in 2002 through exhaustive search
Anthology
发表于 2025-3-27 04:25:38
Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Contentecies (ROS) and c-jun-N-terminal kinase (JNK), and anti-apoptotic signals such as phosphatidylinositides (PI)-3 kinase and protein kinase C are inhibited by ceramide. Sphingosine-1-phosphate (S1P) competes with ceramide-induced cell death by blocking its generation and downstream pathways. This bala
MEAN
发表于 2025-3-27 09:21:03
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破译
发表于 2025-3-27 13:10:58
Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Baseids but also as signaling molecules. LCBs can be converted to other bioactive lipid molecules, ceramide and long-chain base 1-phosphates (sphingosine 1-phosphate in mammals). In theory, the balance of these lipids determines cell fate (the sphingolipid rheostat model). Therefore, the regulation of t
攀登
发表于 2025-3-27 14:50:15
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有权
发表于 2025-3-27 18:28:16
Sphingolipid Traffickingated by selective intracellular trafficking. Transport and sorting of sphingolipids between organelles occurs via vesicular and/or non-vesicular transport mechanisms. Some sphingolipids can also move between the two leaflets of the membrane lipid bilayer and their lateral mobility in the plane of th
听写
发表于 2025-3-27 22:35:18
Current Perspectives on , Sphingolipidsoid long-chain bases, dihydrosphingosine and phytosphingosine, have gained prominence in yeast as regulators of the AGC-type protein kinase Pkh1 and Pkh2, homologs of mammalian phosphoinositide-dependent protein kinase 1 (PDK1). Pkh1 and Pkh2 activate the downstream kinases Pkc1, Ypk1, Ypk2 and Sch9
渗入
发表于 2025-3-28 02:46:47
Generation of Signaling Molecules by De Novo Sphingolipid Synthesisis begins with condensation of L-serine and palmitoyl-CoA, generating sphingoid bases, ceramide, and other species through a series of reactions. Ceramide can also be formed from free sphingoid bases, which has been termed the’ salvage’ pathway. Sphingolipids from both the de novo and salvage pathwa
颂扬国家
发表于 2025-3-28 06:58:03
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chondromalacia
发表于 2025-3-28 11:36:51
Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signalinge in zebrafish and mammals are typical type II integral membrane proteins that occasionally detach from cells after their NH.-terminal anchor is processed. We found that the difference in enzymatic localization is entirely due to the presence of a mucin-like domain located downstream of the NH.-term