Radiculopathy 发表于 2025-3-23 09:48:10
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Proteins and Cell Regulationhttp://image.papertrans.cn/s/image/868445.jpgforestry 发表于 2025-3-24 02:15:44
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Molecular Evolution of Smad Proteins,ed a phylogenetic analysis. To simplify the analysis but retain its explanatory power, we focused on Smad proteins from organisms in three distinct phyla: human, fly, and nematode. Overall, we found that human and fly proteins always cluster together in four subfamilies while three subfamilies conta粗糙滥制 发表于 2025-3-24 09:33:27
, TGF-β Signaling Pathways,y depending on the organism and cell type. . has two TGF-β superfamily signaling pathways that incorporate ligands, receptors, and Smads. There is an interesting ligand, ., that does not appear to require conventional TGF-β superfamily receptors and Smads. In addition, two other TGF-β superfamily li尽忠 发表于 2025-3-24 11:38:45
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,Delineating the TGF-β/Smad-Induced Cytostatic Response,f G1 CDK activities. Smads play key roles in mediating the TGF-β growth-inhibitory response. Smads downregulate the expression of the protooncogene product c-Myc and inhibitor of differentiation Id (Id1, Id2, and Id3) and upregulate the expression of CDK inhibitors p15 and p21. The mechanisms for TG暴露他抗议 发表于 2025-3-24 20:36:52
Smads In Mesenchymal Differentiation,mong the differentiation lineages, mesenchymal tissue differentiation into bone, fat, cartilage or muscle is strongly regulated by TGF-β family members. Smads have shown themselves to function as cell-intrinsic regulators of mesenchymal stem cell differentiation into osteoblasts, adipocytes, chondro夸张 发表于 2025-3-24 23:44:47
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