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Endosialidases: Versatile Tools for the Study of Polysialic Acid,eriophage-borne glycosyl hydrolases that specifically cleave polysialic acid. The crystal structure of an endosialidase reveals a trimeric mushroom-shaped molecule which, in addition to the active site, harbors two additional polysialic acid binding sites. Folding of the protein crucially depends onPulmonary-Veins 发表于 2025-3-22 10:26:28
Development and Applications of the Lectin Microarray,procedures for differential glycan profiling in a rapid and high-throughput manner. Since its first appearance in the literature in 2005, many application methods have been developed essentially on the same platform, comprising a series of glycan-binding proteins immobilized on an appropriate substrMadrigal 发表于 2025-3-22 14:31:53
Sialoside Arrays: New Synthetic Strategies and Applications,ctions, the immune response, the progression of tumor cell metastasis, etc. Despite the importance, the limited access to complex sialosides had prevented extensive studies on the function and significance of sialic acid structural diversity. However, recent advances in synthetic sialoside chemistrysclera 发表于 2025-3-22 20:51:06
SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics,binds with high preference to sialic acids α(2–3)-linked to .-galactose. Although the involvement and relevance of its sialic acid binding activity is still controversial, it could be demonstrated that interactions of MAG with sialylated gangliosides play an important role in axon stability and rege粗糙 发表于 2025-3-22 21:40:54
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